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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PRPF4
All Species:
22.73
Human Site:
Y236
Identified Species:
33.33
UniProt:
O43172
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43172
NP_004688.2
522
58449
Y236
G
D
D
R
P
I
S
Y
C
H
F
S
P
N
S
Chimpanzee
Pan troglodytes
XP_520198
559
62217
Y273
G
D
D
R
P
I
S
Y
C
H
F
S
P
N
S
Rhesus Macaque
Macaca mulatta
XP_001102859
521
58408
Y235
G
D
D
R
P
I
S
Y
C
H
F
S
P
N
S
Dog
Lupus familis
XP_532038
521
58332
Y235
G
D
D
R
P
I
S
Y
C
H
F
S
P
N
S
Cat
Felis silvestris
Mouse
Mus musculus
Q9DAW6
521
58352
Y235
G
D
D
R
P
I
S
Y
C
H
F
S
P
N
S
Rat
Rattus norvegicus
Q5BK30
415
45841
R134
L
H
T
L
E
G
H
R
N
V
V
Y
A
I
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518220
390
43930
P109
I
S
Y
C
H
F
S
P
N
S
K
M
L
A
T
Chicken
Gallus gallus
Q5ZMA2
505
55116
A220
R
M
W
G
L
H
S
A
S
I
P
G
I
L
A
Frog
Xenopus laevis
Q5FWQ6
415
45899
R134
L
H
T
L
E
G
H
R
N
V
V
Y
A
I
Q
Zebra Danio
Brachydanio rerio
Q1LV15
415
45916
R134
L
H
T
L
E
G
H
R
N
V
V
Y
A
I
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q7KNS3
411
46441
D129
L
M
V
S
A
S
E
D
A
T
I
R
I
W
D
Honey Bee
Apis mellifera
XP_393186
525
59172
F229
G
D
T
R
P
I
S
F
C
Q
F
S
P
N
S
Nematode Worm
Caenorhab. elegans
Q10051
492
53189
T211
T
G
I
H
S
T
G
T
P
G
I
T
A
L
D
Sea Urchin
Strong. purpuratus
XP_795434
502
56264
Y216
G
D
T
R
P
I
S
Y
C
R
F
S
P
D
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O22212
554
61823
F252
M
A
L
D
C
S
N
F
G
D
D
R
P
L
T
Baker's Yeast
Sacchar. cerevisiae
P20053
465
52424
S184
P
I
S
A
V
S
L
S
T
D
D
M
V
V
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
92.8
99
99.2
N.A.
98.8
25.4
N.A.
71.2
21
24.1
24.3
N.A.
22.2
58.2
22
62
Protein Similarity:
100
93.1
99.2
99.6
N.A.
99.4
40.6
N.A.
73.3
41.3
41.3
41.5
N.A.
39.6
72.9
40.6
77
P-Site Identity:
100
100
100
100
N.A.
100
0
N.A.
6.6
6.6
0
0
N.A.
0
80
0
80
P-Site Similarity:
100
100
100
100
N.A.
100
6.6
N.A.
13.3
13.3
0
6.6
N.A.
0
86.6
6.6
86.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
40
31.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
55.7
51.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
7
7
0
0
7
7
0
0
0
25
7
25
% A
% Cys:
0
0
0
7
7
0
0
0
44
0
0
0
0
0
0
% C
% Asp:
0
44
32
7
0
0
0
7
0
13
13
0
0
7
13
% D
% Glu:
0
0
0
0
19
0
7
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
7
0
13
0
0
44
0
0
0
0
% F
% Gly:
44
7
0
7
0
19
7
0
7
7
0
7
0
0
0
% G
% His:
0
19
0
7
7
7
19
0
0
32
0
0
0
0
0
% H
% Ile:
7
7
7
0
0
44
0
0
0
7
13
0
13
19
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% K
% Leu:
25
0
7
19
7
0
7
0
0
0
0
0
7
19
0
% L
% Met:
7
13
0
0
0
0
0
0
0
0
0
13
0
0
0
% M
% Asn:
0
0
0
0
0
0
7
0
25
0
0
0
0
38
0
% N
% Pro:
7
0
0
0
44
0
0
7
7
0
7
0
50
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
7
% Q
% Arg:
7
0
0
44
0
0
0
19
0
7
0
13
0
0
0
% R
% Ser:
0
7
7
7
7
19
57
7
7
7
0
44
0
0
44
% S
% Thr:
7
0
32
0
0
7
0
7
7
7
0
7
0
0
13
% T
% Val:
0
0
7
0
7
0
0
0
0
19
19
0
7
7
0
% V
% Trp:
0
0
7
0
0
0
0
0
0
0
0
0
0
7
0
% W
% Tyr:
0
0
7
0
0
0
0
38
0
0
0
19
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _